Holy….

Originally from Anne.

Looks like Ivermectin might be a cure for pancreatic cancer. Other cancers as well.

From the article, with thoughts at bottom:
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.

Abstract

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies. Satoshi ōmura and William C. Campbell won the 2015 Nobel Prize in Physiology or Medicine for the discovery of the excellent efficacy of ivermectin against parasitic diseases. Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways. This suggests that ivermectin may be an anticancer drug with great potential. Here, we reviewed the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death and discussed the prospects for the clinical application of ivermectin as an anticancer drug for neoplasm therapy.

1. Introduction

Ivermectin(IVM) is a macrolide antiparasitic drug with a 16-membered ring derived from avermectin that is composed of 80% 22,23-dihydroavermectin-B1a and 20% 22,23-dihydroavermectin-B1b []. In addition to IVM, the current avermectin family members include selamectin, doramectin and moxidectin [] (Fig. 1 ). IVM is currently the most successful avermectin family drug and was approved by the FDA for use in humans in 1978 []. It has a good effect on the treatment of parasitic diseases such as river blindness, elephantiasis, and scabies. The discoverers of IVM, Japanese scientist Satoshi ōmura and Irish scientist William C. Campbell, won the Nobel Prize in Physiology or Medicine in 2015 [,]. IVM activates glutamate-gated chloride channels in the parasite, causing a large amount of chloride ion influx and neuronal hyperpolarization, thereby leading to the release of gamma-aminobutyric acid (GABA) to destroy nerves, and the nerve transmission of muscle cells induces the paralysis of somatic muscles to kill parasites [,]. IVM has also shown beneficial effects against other parasitic diseases, such as malaria [,], trypanosomiasis [], schistosomiasis [], trichinosis [] and leishmaniasis [].

IVM not only has strong effects on parasites but also has potential antiviral effects. IVM can inhibit the replication of flavivirus by targeting the NS3 helicase []; it also blocks the nuclear transport of viral proteins by acting on α/β-mediated nuclear transport and exerts antiviral activity against the HIV-1 and dengue viruses []. Recent studies have also pointed out that it has a promising inhibitory effect on the SARS-CoV-2 virus, which has caused a global outbreak in 2020 []. In addition, IVM shows potential for clinical application in asthma [] and neurological diseases []. Recently scientists have discovered that IVM has a strong anticancer effect.

Since the first report that IVM could reverse tumor multidrug resistance (MDR) in 1996 [], a few relevant studies have emphasized the potential use of IVM as a new cancer.

[end quote, start of thoughts.]

Holy crap. This might explain why Big Pharma is fighting so hard to marginalize the use of Ivermectin. It’s not just that it would nuke the profits from the Covid19 vaccine gene therapy. It could nuke the tens of billions in revenue for cancer treatments, possibly other diseases and medications as well. It would absolutely crater their profits, and cut the government funding stream for cancer research. From the Government’s perspective, not having so many people die young from cancer will do horrible things to the social safety net retirement plans; if you think Social Security is in bad shape now, what happens if the death from cancer rate drops by half or more? Ouch! Both groups benefit from people getting sick and dying young.

1 thought on “Holy….

  1. Absolutely. Drug OD’s are an empidemic in this country at 50 per 100,000. Cancer death stand at 150 per 100,00. And you don’t hear much about it do we?
    Spot on Rolf!

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